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What is it?

Hemophilia A is the most common form of hemophilia, caused by a deficiency of clotting factor VIII. It is an inherited bleeding disorder where the blood does not clot properly.

• Affects approximately 1 in 5,000 male births
• Caused by mutations in the F8 gene on the X chromosome
• Ranges from mild to severe based on factor levels
• Treatment involves factor VIII replacement therapy

What is it?

Hemophilia B, also called Christmas Disease, is caused by a deficiency of clotting factor IX. It is less common than Hemophilia A but presents similarly.

• Affects approximately 1 in 30,000 male births
• Caused by mutations in the F9 gene on the X chromosome
• Named after Stephen Christmas, the first patient described
• Treated with factor IX replacement or gene therapy

What is it?

Von Willebrand Disease is the most common inherited bleeding disorder, affecting both males and females equally. It involves a deficiency or dysfunction of Von Willebrand factor.

• Affects up to 1% of the general population
• Three main types: Type 1, Type 2, and Type 3
• Often underdiagnosed, especially in women
• Treatment includes desmopressin (DDAVP) or factor replacement